Muscarinic Receptors in Mood Disorders

Grant number: 628669 | Funding period: 2010 - 2012

Completed

Abstract

The causes of bipolar disorder and major depressive disorder, which effect many Australians, remain unknown. We have recently shown decreases in muscarinic receptors in the brain of people with bipolar disorder and major depressive disorder. Muscarinic receptors are important in maintaining the functions of the brain that seem to be affected in people with bipolar disorder and major depressive disorder. Here we seek to understand how changes in muscarinic receptors occur in both disorders.

Related publications (3)

The use of a modified [3H]4-DAMP radioligand binding assay with increased selectivity for muscarinic M3 receptor shows that cortical CHRM3 levels are not altered in mood disorders

WJ Jeon, AS Gibbons, B Dean

2013-12-02

[<sup>3</sup>H]4-DAMP is a radioligand that has been used to quantify levels of the muscarinic receptor CHRM3 protein in situ. How..

Decreased cortical muscarinic M1 receptors in schizophrenia are associated with changes in gene promoter methylation, mRNA and gene targeting microRNA

E Scarr, JM Craig, MJ Cairns, MS Seo, JC Galati, NJ Beveridge, A Gibbons, S Juzva, B Weinrich, M Parkinson-Bates, AP Carroll, R Saffery, B Dean

2013-03-01

Many studies have shown decreased cortical muscarinic M1 receptors (CHRM1) in schizophrenia (Sz), with one study showing Sz can be..

Muscarinic M1 receptor sequence: Preliminary studies on its effects on cognition and expression

E Scarr, S Sundram, A Deljo, TF Cowie, AS Gibbons, S Juzva, A Mackinnon, SJ Wood, R Testa, C Pantelis, B Dean

2012-06-01

It has been reported that people with schizophrenia who are homozygous at the c.267C>A single nucleotide polymorphism of the choli..

University of Melbourne Researchers

Brian Dean Florey Department of Neuroscience and Mental Health